Sudden system slowdown, start up and software functional issues

The following happened when I started up my iMac in the morning. The only thing I did the night before that was outside my normal email/browsing/dreamweaver routine was to plug in my iPad to update apps and download an instagram phone app. iTunes did take me to my billing login and asked me to confirm CVV code which I hadn't expected. It told me I was using a different computer than the one I usually use - I wasn't.  Other than that, nothing seemed out of the ordinary all evening
Following morning symptoms as follows
Start up
Slow start up grey screen with progress bar and wheel which leads to a log on screen. Normally no progress bar and no need to login.
Desktop appears but the 20 or so files and folders take a while to appear. The Finder bar top of screen does not appear until I click on the Finder icon in the dock. Wacom tablet doesn't function and preferences for the wacom when clicked throws  up a warning " Wacom tablet driver has a problem - reboot system or reinstall or update the driver. Items that usually start up such as Skype and stickies do not open automatically. Icons that would normally appear on the finder bar top screen such as dropbox and sophos do not appear.
Other behaviours
Clicking a link to a web article from an email throws up the prompt "You are opening the application 'Firefox' for the first time. Are you sure you want to open this application?"
Documents in Pages appear blank
All operations are slow/delayed
Disk Utility: Verifying disk permissions shows about 1200 permission errors. Repaired them, verifyed again and it looks like they are all still wrong.
Tried  running sophos but it seems to sit in 'Calculating...' mode and doesn't indicate it has scanned any files.
Does anyone have any idea what is going on here, what might have caused it and what the best course of action might be? Please note, I will be going away on holiday for a week on Sunday, so I will not be able to respond to anyone between the 14th and 20th April.
Thanks
Also just removed sophos and downloaded it anew. The install is taking an age - it's been 15 minutes now. Could be part of the general malaise or maybe it just isn't going to install.

If this started happening without your having made any changes and without a warning of low disk space, then it's likely that the startup drive, or some other hardware component, is failing. Back up all data immediately, then run Apple Diagnostics or the Apple Hardware Test.
Even if the test is negative, you should make a "Genius" appointment at an Apple Store to have the machine tested more thoroughly.

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