USB Device Recognized by Mac, Not by Application

The general questions are why would the Mac recognize a USB device but the application software for the device "suddenly" (after a couple weeks of not using it) stop recognizing it and stop working, and what is the solution?
Specifically, I am running Leopard 10.5.5 on a MacBook Pro. Xrite’s Colormunki (monitor calibration and printer profiler device and software) worked twice, and now the device does not function with its software. The MacBook sends power to the Colormunki (its internal light flashes briefly as it is first connected to the Mac), the Mac recognizes the Colormunki (it shows up by name in the System Profiler), but the Colormunki software does not recognize that it is connected. A software alert message says it is not connected and asks that it be connected. Disconnecting and then reconnecting the device does not solve the problem.
At the suggestions of tech support at both Apple and Xrite (both have been very patient and persistent in trying to solve the problem), I have uninstalled the Colormunki software (using Xrite’s Colormunki Uninstall utility) and reinstalled it, reset the Pram, disconnected the Mac from AC and removed the battery, repaired permissions, and “repaired” the hard drive. I have set up a test user account on the Mac to try to determine if the problem is user-specific; it is not. I have tried a different Colormunki on the Mac with no other peripherals attached. It didn’t work either.
Both tech supports agree that this is an OS problem, not an application problem. Apple’s final suggestion was to do an archive and restore. This can be a bit of a hassle, the more so because I don’t really know if it will work. Is there a simpler solution or an explanation of what might have happened to cause the problem?

Using USB devices that take power from a computer is, in my opinion, a very iffy thing to do.
On my older MBP, I can use my Pinnacle HDTV stick only on the right-hand USB port. On the left, after a time, the USB port reverts to USB 1.1.
There is a very strict power limit for USB devices powered from the computer and exceeding this limit can damage the port or at least shut it down until a reboot.
It's best to use only USB devices that have their own power, or run them through a USB2 powered hub.
I am not sure this is the solution to your issue, but many have had similar experiences to mine using USB ports on MBPs.
if you go to the MBP forum and search for USB you will find a plethora of issues.
http://discussions.apple.com/category.jspa?categoryID=190

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