First RFC call failed, config not loaded. Check the System landscape configuration.

Dear Experts,
We are getting below error on portal while using the BEX query in BI system.
Error:
BEx Web Application
Error: First RFC call failed, config not loaded. Check the System landscape configuration.
Exception occurred while processing the current request; this exception cannot be handled by the application or framework
Failed to process request; contact your system administrator
To facilitate analysis of the problem, keep a copy of this error page
We are sorry for the inconvenience.
As the ITS & WEB AS connection tests go successful on object created for BI system in portal.
Kindly suggest me on this issue..
Thanks,
Bharath.

Hi Bharath,
Please go through the below SAP Note and let me know if this helps.
1903392 - Error: First RFC call failed, config not loaded
BR,
Anurag

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