The USB ports on my iMac work fine in some locations, but if the iMac is in my office, nothing happens when I click the mouse.

The USB ports on my iMac (purchased in 2013) were working fine.  Suddenly, clicking my mouse elicits no response.  When I move the iMac to the Apple store, it works fine -- and it works fine in other rooms in my house.  Why won't it work in my study?

Have you tried plugging the mouse into another USB port on your Mac?  Try gently wiggling the connector at each end of the calble while trying to use the mouse.
OT

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