Will Disabling IPv6 harm a Windows 8 or Server 2012 R2?

I have a script that was written for Windows 7 and server 2008. I would like to know if it was harm a Windows 8 or any build of Server 2012 box. If so, could you please list what it would harm.
It was create to help with speed issues for an older network based program.
Thanks in advance.
netsh interface tcp set global autotuning=disabled
ocsetup MSRDC-Infrastructure /uninstall
@Echo off
@ECHO Windows Registry Editor Version 5.00 > %TEMP%\DisableIPv6.reg
@ECHO [HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Tcpip6\Parameters] >> %TEMP%\DisableIPv6.reg
@ECHO "DisabledComponents"=dword:ffffffff >> %TEMP%\DisableIPv6.reg
@ECHO [HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\LanmanServer\Parameters] >> %TEMP%\DisableIPv6.reg
@ECHO "Smb2"=dword:00000000 >> %TEMP%\DisableIPv6.reg
REGEDIT /S %TEMP%\DisableIPv6.reg
ipconfig /flushdns
sc config CscService start= disabled
sc config lanmanworkstation depend= bowser/mrxsmb10/nsi
sc config mrxsmb20 start= disabled

Hi:
I don't think anyone can say for sure if it would cause any harm to any build of Windows 8 or Server 2012Rx. No one would have tested disabling IPV6 on all the possible combinations. The conventional wisdom is to NOT disable IPV6, but given special
circumstances I suppose it might be done:
http://blogs.technet.com/b/sbs/archive/2008/10/24/issues-after-disabling-ipv6-on-your-nic-on-sbs-2008.aspx
While written for Server 2008 and SBS 2008, you might want to check the above link for ideas. About half way down it discusses some considerations.
Are you still running some older program that might benefit from this? If so, have you actually tested it without disabling IPV6 on say one server and one station. It would be easy enough to test then reverse the changes if there was no perceived
benefit.
Larry Struckmeyer[MVP] If your question is answered please mark the response as the answer so that others can benefit.

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