Applications Start Page Profile Option Causing Issues

Hello Oracle Gurus,
I'm having an issue in a 12.1.3 instance that I think may be related to the "Applications Start Page" profile option.
For testing purposes, we set the profile to a specific Self-Service page at the Site level. We eventually removed the Site level profile and added it at the user level just for specific users, but since the Site-level profile was set, every time we click the Home link in the upper right-hand navigation, we get an "unexpected error." If we attempt to log in as a user that does not have the Applications Start Page profile defined, we also get an unexpected error.
After getting the error using either of the methods listed above, if we then try to navigate back to the login page, the instance throws a 500 Internal Error.
If we close the browser and navigate to the instance again, we're able to log in without any issues with user accounts that have an Applications Start Page profile defined.
Our "Self Service Personal Framework Mode" is set to "Framework Only" at the site level.
Bouncing Apache seems to resolve the issue temporarily, but then it comes back again a few hours later...
We've opened a Service Request, but has anyone else run into this before / have any ideas on how to fix it?
Here are some related Metalink notes from 11.5.10:
729375.1 (About the Applications Start Page profile option)
331814.1 (Error on Personal Home Page when returning to 'Home' link)
Thanks!
Anne

The issue is not specific to a responsibility or application.
Here is the error:
Fatal NI connect error 12170.
VERSION INFORMATION:
     TNS for Linux: Version 11.1.0.7.0 - Production
     Unix Domain Socket IPC NT Protocol Adaptor for Linux: Version 11.1.0.7.0 - Production
     Oracle Bequeath NT Protocol Adapter for Linux: Version 11.1.0.7.0 - Production
     TCP/IP NT Protocol Adapter for Linux: Version 11.1.0.7.0 - Production
Time: 27-JAN-2011 09:46:02
Tracing not turned on.
Tns error struct:
ns main err code: 12535
TNS-12535: TNS:operation timed out
ns secondary err code: 12560
nt main err code: 505
TNS-00505: Operation timed out
nt secondary err code: 110
nt OS err code: 0
Client address: (ADDRESS=(PROTOCOL=tcp)(HOST=172.30.31.107)(PORT=1502))
Thu Jan 27 09:53:30 2011
Incremental checkpoint up to RBA [0x42.e3635.0], current log tail at RBA [0x42.e37e1.0]
Thu Jan 27 10:13:31 2011
Incremental checkpoint up to RBA [0x42.e602b.0], current log tail at RBA [0x42.e6146.0]
Thu Jan 27 10:33:33 2011
Incremental checkpoint up to RBA [0x42.e7bc9.0], current log tail at RBA [0x42.e7d51.0]
Thu Jan 27 10:53:35 2011
Incremental checkpoint up to RBA [0x42.e995f.0], current log tail at RBA [0x42.e9ac9.0]
Thu Jan 27 11:13:37 2011
Incremental checkpoint up to RBA [0x42.ec163.0], current log tail at RBA [0x42.ec3f7.0]
Thu Jan 27 11:23:48 2011
Starting background process CJQ0
Thu Jan 27 11:23:48 2011
CJQ0 started with pid=8, OS id=17239
Thu Jan 27 11:33:39 2011
Incremental checkpoint up to RBA [0x42.ee08f.0], current log tail at RBA [0x42.ee216.0]
Thu Jan 27 11:53:41 2011
Incremental checkpoint up to RBA [0x42.efd07.0], current log tail at RBA [0x42.eff13.0]
Thu Jan 27 11:54:02 2011
Stopping background process CJQ0
Thu Jan 27 12:13:43 2011
Incremental checkpoint up to RBA [0x42.f25c0.0], current log tail at RBA [0x42.f2e4b.0]
Thu Jan 27 12:33:45 2011
Incremental checkpoint up to RBA [0x42.f4cae.0], current log tail at RBA [0x42.f4e4b.0]
Thu Jan 27 12:53:47 2011
Incremental checkpoint up to RBA [0x42.f6e8a.0], current log tail at RBA [0x42.f6fb7.0]
Thu Jan 27 13:13:50 2011
Incremental checkpoint up to RBA [0x42.fa3d0.0], current log tail at RBA [0x42.fa845.0]
Thu Jan 27 13:33:52 2011
Incremental checkpoint up to RBA [0x42.fc7d9.0], current log tail at RBA [0x42.fc989.0]
Thu Jan 27 13:53:55 2011
Incremental checkpoint up to RBA [0x42.fed4e.0], current log tail at RBA [0x42.ff12e.0]

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