Excel 2010 not always taking priority when opened

Hello,
I have a user who from time to time cannot click on any commands in Excel. He has to switch to another window, ie his desktop, and then back for commands to become active.
Details:
Office 2010 Pro SP2 32-bit
Windows 7 Pro SP1 64-bit
and the computer is on our domain.
He is the only person experiencing(or reporting) this issue.

Hi,
Did the issue occur only in the Excel or all the Office suits? Did he get some error messages when he click on any commands in Excel?
Please try the below methods to narrow down the issue:
1. Start Excel in safe mode by pressing and holding Ctrl while you start the program or by using the "/safe" (that is,
excel.exe /safe) option when you start the program from the command line. If it works fine in safe mode, please check the Excel Add-ins and disable them.
2. Use the administer account to logon the PC. If it works fine, please check the user profile.
3. Repair Office 2010.
4. Upgrade the latest patches.
Regards,
George Zhao
TechNet Community Support

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    Come back and mark the replies as answers if they help and unmark them if they provide no help.
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