Intermittent hl7 tcpip problem

In order to move our hl7 interfaces from the 4.53 version to the 5.1.2 caps version we have a pass-through in the 4.53 system. This sends along a copy of one of the main feeds from our his system to 5.1.2.
The problem is 3 times in the last couple of months the 5.1.2 side reports that it is sending an ack and the 4.53 side does not report receiving the ack. 4.53 then times out and drops/restarts the connection where the message is sent again and the ack is sent again but not seen. I have a file client that I write the logging to in the 5.12 side that writes the ack to the file 1 line after the ack is sent. There are no try catches in this part of the code so the ack would not show up in the log if there were an error. The 4.53 sides logs are set high enough to see the ack in the log but it is not there.
We are using ha and I have failed over to the other server thinking that if everything were stopped and restarted I would be ok. The same issue occurred on the other server once the failover was complete. If I leave it in this loop long enough on occasion one will process correctly.
The only solution that I have found is to stop the domain, delete the domain, recreate the domain, rebuild the projects, and redeploy the projects. This has worked every time so it makes me thing that something is getting corrupted in the domain. The problem is we have numerous projects and it takes quite some time to rebuild and redeploy them all and we are not even close to having all of the 4.53 stuff moved over so there will be many more requiring much more time in the future.
Also I mentioned that this was happening to one of the lines, we have another line from our his that is being passed through 4.53 that is almost a duplicate traffic wise and this has never happened to it. I compared all of the settings in the eway and they are all the same.
This is pretty much stopping us from moving forward. If anyone has any ideas they will be greatly appreciated.

Well thanks for the 100s of helpful replies, like ZERO LOL
Anyway screen sorted took it to Meadowhalls Apple center, they took one look and changed it FREE of charge, so much for sending it into apple care center, bunch of dimwits they claimed it was ok and you only had to use it to see it was clearly not.
so moral of the story. DON'T ask here, if your question has more than one answer option, must be too hard for you lot to answer.

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