Office 2013 outlook (not responding) opening attachments over a WAN link

Before I get to the question I'll give you some info about our arcitecture.
We have 7 remote sites each with 5mb connections.
5-10 computer at each site
We are running exchange 2010 centrally from one server on a 20mb connection.
All clients are running windows 7 64bit with office 2013
We recetly upgraded from office 2003 to 2013 when this problem started.
If a user clicks on an attachment from one of our remote sites, and if the attachment is larger than 150kb the outlook client displays (not responding) for up to two minutes. If you wait long enough the attachment will open without error. It
doesnt matter if its a word docuemnt, PDF, JPG they all respond the same. There are several active application add-ins running I have not tried to disable any of them yet.
Acrobat PDFMaker office com addin
Lync meeting addin for microsoft office 2013
microsoft exchange addin
microsoft sharepoint server colleague import addin
microsoft vba for outlook addin
onenote notes about outlook items
outlook social connector 2013
symantec endpoint protection outlook addin
I should also mention theres plenty of bandwidth free at both ends of the pipe. Moving the same file size accross the network literally takes only takes a second or less.
How can I go about troubleshootng this issue further?
Has anyone else experieced this?
What have you done to fix it?

Hi,
According to your description, I understand that all attachments in Outlook are opened slowly since updating Outlook 2003 to 2013. Please confirm whether all users encounter this issue. Also check whether the issue continues in cached mode and in OWA.
Based on your post, I suggest we can try to disable the following add-ins to check whether the issue persists:
Acrobat PDFMaker office com addin
symantec endpoint protection outlook addin
If there is any updates, please feel free to let us know.
Thanks,
Winnie Liang
TechNet Community Support

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Office 365 forum:
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Please remember to mark the replies as answers if they help and unmark them if they provide no help. If you have feedback for TechNet Subscriber Support, contact
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[email protected]

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We have an exchange 2010 server with 2 load balanced CAS server and Mailbox servers in a DAG. We have a few domain
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We have an exchange 2010 server with 2 load balanced CAS server and Mailbox servers in a DAG. We have a few domain
name accepted (will call it firstdomain.com and seconddomain.com) but only one is in certificate (firstdomain.com).
The issue is - when user with default email @seconddomain.com try to set “Out Of Office” from outlook (2010 with all service
packs and updates) he is getting “ Your Out of Office settings cannot be displayed, because the server is currently unavailable. Try again later” where
setting it from webmail works fine and setting it from outlook for users with @firstdomain.com reply address works fine.
we have both internal and external urls for all virtual directories set to external
host address (https://mail.firstdomain.com
  etc). All the users are on intranet with local ip subnets (sites connected via vpns ), all the routing is in place and DNS points to correct ip addresses.
Autodiscover works fine (tested in outlook ) and giving correct address for OOF link
( https://mail.firstdomain.com/ews/exchange.asmx)
wich opens fine if entered into address bar in IE so its NOT AN AUTODISCOVER issue .
I enabled logging in outlook and thats what I am getting in there:
1600       0x49763D20        02/02/15 16:50:44
+++++++++++++++++++++++++++++++
1600       0x49763D20        02/02/15 16:50:44
OWINHTTP SEND HTTP REQUEST BEGIN
1600       0x49763D20        02/02/15 16:50:44
Profile=Outlook
1600       0x49763D20        02/02/15 16:50:44
  [email protected]
1600       0x49763D20        02/02/15 16:50:44
URL=https://mail.firstdomain.com/ews/exchange.asmx
1600       0x49763D5F        02/02/15 16:50:45
GetLastError=0; httpStatus=401.
1600       0x49763D5F        02/02/15 16:50:45
OWinHtpp disabled auth schemes:
1600       0x49763D5F        02/02/15 16:50:45
<NONE>
1600       0x49763D5F        02/02/15 16:50:45
OWinHtpp supported auth schemes:
1600       0x49763D5F        02/02/15 16:50:45
Negotiate
1600       0x49763D5F        02/02/15 16:50:45
NTLM
1600       0x49763D5F        02/02/15 16:50:45
Basic
1600       0x49763D5F        02/02/15 16:50:45
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1600       0x49763D5F        02/02/15 16:50:45
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1600       0x49763D5F        02/02/15 16:50:45
Negotiate
1600       0x49763D9D       02/02/15 16:50:45
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1600       0x49763DAD       02/02/15 16:50:45
OWINHTTP SEND HTTP REQUEST END
1600       0x49763DAD       02/02/15 16:50:45
Last thing - we are using proxy server and with proxy off it works fine although all
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Aside from obvious question - what can be wrong and what to test next, another question
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Last thing - we are using proxy server and with proxy off it works fine although all
possible exchange server hosts/domains/ip addresses excluded from proxy.
Aside from obvious question - what can be wrong and what to test next, another question
is - how can I check/monitor setting OOF on server side (log files etc)?
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Hi,
According to your description, I understand that Outlook client with second domain name cannot use OOF setting and get an error “Your Out of Office settings cannot be displayed, because the server is currently unavailable.” However OWA works fine.
If I misunderstand your concern, please do not hesitate to let me know.
I want to double confirm whether all account or some special user experience this question.
Would you please try to reconfigure Outlook profile in other Computer, Outlook version and return the results?
If this issue only appeared on Outlook 2010, please refer to below link to troubleshooting:
https://support.microsoft.com/kb/2596516?wa=wsignin1.0
Please try to run ExBPA to test OOF to get more details about this question. Additional, I find a similar thread about your question, for your reference:
https://social.technet.microsoft.com/Forums/exchange/en-US/81ebc1de-c899-4097-b224-a0e4b33e4162/users-cant-open-out-of-office-assistant
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Hi,
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Office 2013 outlook (not responding) opening attachments over a WAN link

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