The e-mail message could not be sent. Make sure the outgoing e-mail settings for the server are configured correctly

I have a 2 server SharePoint farm.
All outgoing emails were working fine.
I just restarted both servers and now after that none of the emails are being sent. I am using OOB publishing workflow and it shows message:
The e-mail message could not be sent. Make sure the outgoing e-mail settings for the server are configured correctly.
Even if I setup Alert on some list, it doesn't send email.
I have checked that outgoing email setting in CA is defined and like I said it was working fine without problems but after restart it is showing error.
What could be the cause of this and how to fix it?
EDIT
I removed outgoing mail server in CA, added again and restart IIS but still emails from OOB workflow is not being sent. But email from Alerts are being sent. Don't know what to do now.

This is really weird, It works when an alert is set but workflows doesn't send emails... Can you create a simple 1 Step workflow in SPD to send an email when a specific field is set. See if this sends an email..
AJ MCTS: SP 2010 Configuration MCSA: Windows 7 If you find this post useful kindly please mark it as an answer :) TY
I created a test workflow which sends email to user and it is also not sending email. But I am getting email from SharePoint regarding "variation" page changes as well as alerts which I told above.

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